PTHR34216

Polysaccharide Deacetylase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short namePolysacch_Deacetylase
AI

Description

AI-generatedUnreviewed
The polysaccharide deacetylase family includes enzymes that catalyze the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG or PIA), a biofilm adhesin polysaccharide. This modification is essential for the attachment of the polysaccharide to the bacterial cell surface, as it introduces positive charges into the neutral PIA polymer, facilitating electrostatic interactions. The deacetylation process is a critical step in biofilm formation, colonization, and contributes to bacterial virulence by enhancing resistance to neutrophil phagocytosis and human antibacterial peptides. Some family members are also specific to the heteropolysaccharide gellan, cleaving its glycosidic bonds to release tetrasaccharide units. The family plays a significant role in bacterial pathogenicity and biofilm-related infections.
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