PTHR34981

CELL DIVISION PROTEIN ZAPA

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR007838

This entry represents a structural domain found in the cell division protein ZapA, as well as in related proteins. This domain has a core structure consisting of two layers alpha/beta, and has a long C-terminal helix that forms dimeric parallel and tetrameric antiparallel coiled coils
[1]
. ZapA interacts with FtsZ, where FtsZ is part of a mid-cell cytokinetic structure termed the Z-ring that recruits a hierarchy of fission related proteins early in the bacterial cell cycle. ZapA drives the polymerisation and filament bundling of FtsZ, thereby contributing to the spatio-temporal tuning of the Z-ring.

References
Imported from IPR007838

1.The crystal structure of ZapA and its modulation of FtsZ polymerisation. Low HH, Moncrieffe MC, Lowe J. J. Mol. Biol. 341, 839-52, (2004). View articlePMID: 15288790

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