This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | Class-IV_PLP-Dep_Aminotrnsfr AI |
Description
AI-generatedUnreviewed
The Class-IV Pyridoxal-Phosphate-Dependent Aminotransferase family comprises enzymes that catalyze the transfer of amino groups from amino acids to alpha-keto acids via a ping-pong mechanism. Members of this family are involved in the metabolism of branched-chain amino acids such as leucine, isoleucine, and valine, as well as D-amino acids including D-alanine, D-leucine, D-aspartate, D-glutamate, D-aminobutyrate, D-norvaline, and D-asparagine. These enzymes play crucial roles in processes such as the synthesis of bacterial cell wall components and the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. The family includes both specific branched-chain-amino-acid aminotransferases and D-alanine aminotransferases, as well as multifunctional enzymes with aminodeoxychorismate lyase activity, contributing to folate biosynthesis.