PTHR42743

Class-IV Pyridoxal-Phosphate-Dependent Aminotransferase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameClass-IV_PLP-Dep_Aminotrnsfr
AI

Description

AI-generatedUnreviewed
The Class-IV Pyridoxal-Phosphate-Dependent Aminotransferase family comprises enzymes that catalyze the transfer of amino groups from amino acids to alpha-keto acids via a ping-pong mechanism. Members of this family are involved in the metabolism of branched-chain amino acids such as leucine, isoleucine, and valine, as well as D-amino acids including D-alanine, D-leucine, D-aspartate, D-glutamate, D-aminobutyrate, D-norvaline, and D-asparagine. These enzymes play crucial roles in processes such as the synthesis of bacterial cell wall components and the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. The family includes both specific branched-chain-amino-acid aminotransferases and D-alanine aminotransferases, as well as multifunctional enzymes with aminodeoxychorismate lyase activity, contributing to folate biosynthesis.
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