PTHR42918

Lysine--tRNA ligase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameLysyl-tRNA_synthetase
AI

Description

AI-generatedUnreviewed
This family of proteins is involved in the specific attachment of lysine to its cognate tRNA, a critical step in protein synthesis. Members of this family are known as lysine--tRNA ligases or aminoacyl-tRNA synthetases. They catalyze a two-step reaction where lysine is first activated by ATP to form a lysyl-adenylate intermediate and then transferred to the acceptor end of the tRNA. Some members also have additional functions, such as the synthesis of diadenosine tetraphosphate (Ap4A), a signaling molecule that can modulate stress responses, and the post-translational modification of translation elongation factor P (EF-P).
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