This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | Lysyl-tRNA_synthetase AI |
Description
AI-generatedUnreviewed
This family of proteins is involved in the specific attachment of lysine to its cognate tRNA, a critical step in protein synthesis. Members of this family are known as lysine--tRNA ligases or aminoacyl-tRNA synthetases. They catalyze a two-step reaction where lysine is first activated by ATP to form a lysyl-adenylate intermediate and then transferred to the acceptor end of the tRNA. Some members also have additional functions, such as the synthesis of diadenosine tetraphosphate (Ap4A), a signaling molecule that can modulate stress responses, and the post-translational modification of translation elongation factor P (EF-P).