This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | Bact_Sigma-Reg AI |
Description
AI-generatedUnreviewed
The protein family described is involved in regulatory processes related to stress response and sporulation in bacteria. Members of the family function as regulators of sigma factors, which are proteins that control the transcription of specific sets of genes. They exhibit phosphatase activity, often dephosphorylating specific proteins to activate sigma factors in response to environmental or energy stress. Some members also have kinase activity and can phosphorylate other proteins, playing a role in signal transduction pathways. The family includes proteins that participate in the cross-regulation of carbon and glucose metabolisms, as well as proteins that act as independent regulators sensitive to osmosensory signals. They are characterized by the presence of domains such as PAS, which may sense cellular energy levels, and anti-sigma factor domains, which are involved in the regulation of sigma factor activity.
Integrated to
External Links
Representative structure
3eea: The crystal structure of the GAF domain/HD domain protein from Geobacter sulfurreducens