PTHR43222

Nudix Hydrolase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameNudix_Hydrolase
AI

Description

AI-generatedUnreviewed
The Nudix hydrolase family is characterized by its ability to hydrolyze various nucleoside diphosphate derivatives. Members of the NudJ subfamily, such as Phosphatase NudJ, are implicated in the hydrolysis of specific substrates like 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) and thiamine pyrophosphate (TPP), releasing monophosphate forms and inorganic orthophosphate. Some proteins within the family, like the 8-oxo-(d)GTP phosphatases, are involved in the detoxification of oxidized nucleotides, converting 8-oxo-dGTP to 8-oxo-dGDP, and potentially further to 8-oxo-dGMP, playing a crucial role in cellular response to oxidative stress. The family also includes enzymes that can hydrolyze diadenosine polyphosphates. The Nudix hydrolase family is essential for maintaining nucleotide pool balance and preventing the incorporation of damaged nucleotides into DNA and RNA, thereby safeguarding genomic integrity.
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