PTHR43275

Isocitrate and isopropylmalate dehydrogenases
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameICDH/IPMDH
AI

Description

AI-generatedUnreviewed
This family of proteins includes enzymes that catalyze the oxidative decarboxylation of various substrates. Members of this family are involved in key metabolic pathways, such as the tricarboxylic acid cycle and the leucine biosynthesis pathway. They function by oxidizing specific substrates, which typically results in the formation of a keto acid and the release of carbon dioxide. Some family members have dual roles, participating in both glutamate and lysine biosynthesis, and can utilize NAD(+) as a cofactor. Other members exhibit broader substrate specificity, capable of catalyzing reactions involving tartrate, malate, and isocitrate. The enzymatic activities of this family are essential for various cellular processes, including energy production and amino acid synthesis.
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