This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | MetAP_Type1 AI |
Description
AI-generatedUnreviewed
The Methionine Aminopeptidase Type 1 family is characterized by its enzymatic function in the cotranslational processing of nascent proteins. Members of this family are responsible for the removal of the N-terminal methionine from newly synthesized proteins, particularly when the second residue is small and uncharged, such as Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val. This cleavage often requires the prior deformylation of N(alpha)-formylated initiator methionine. The family is part of the peptidase M24A family and plays a crucial role in protein maturation and function by regulating the N-terminus of proteins, which can be critical for protein stability, localization, and interaction with other molecules.
External Links
Representative structure
4ook: Third Metal bound M.tuberculosis methionine aminopeptidase