PTHR43475

Methylthioribose-1-phosphate isomerase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameMTR-1-P_isomerase
AI

Description

AI-generatedUnreviewed
This family of proteins includes enzymes that are involved in the isomerization of specific phosphorylated sugars. The primary function of these enzymes is to catalyze the interconversion of methylthioribose-1-phosphate (MTR-1-P) and methylthioribulose-1-phosphate (MTRu-1-P), which is a key step in the methionine salvage pathway. This pathway recycles methylthioadenosine, a by-product of polyamine biosynthesis, back into methionine, an essential amino acid. Some members of this family also catalyze the isomerization of 5-deoxyribose 1-phosphate to 5-deoxyribulose 1-phosphate, a reaction that is part of a salvage pathway for 5-deoxyribose, a by-product of radical S-adenosylmethionine enzymes. The enzymes in this family exhibit strict substrate specificity and are crucial for maintaining cellular methionine levels and for the detoxification of certain by-products.
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