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Member database | PANTHER |
PANTHER type | family |
Short name | MTR-1-P_isomerase AI |
Description
AI-generatedUnreviewed
This family of proteins includes enzymes that are involved in the isomerization of specific phosphorylated sugars. The primary function of these enzymes is to catalyze the interconversion of methylthioribose-1-phosphate (MTR-1-P) and methylthioribulose-1-phosphate (MTRu-1-P), which is a key step in the methionine salvage pathway. This pathway recycles methylthioadenosine, a by-product of polyamine biosynthesis, back into methionine, an essential amino acid. Some members of this family also catalyze the isomerization of 5-deoxyribose 1-phosphate to 5-deoxyribulose 1-phosphate, a reaction that is part of a salvage pathway for 5-deoxyribose, a by-product of radical S-adenosylmethionine enzymes. The enzymes in this family exhibit strict substrate specificity and are crucial for maintaining cellular methionine levels and for the detoxification of certain by-products.