PTHR43490

Short-chain Dehydrogenases/Reductases (SDR)
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameSDR
AI

Description

AI-generatedUnreviewed
The Short-chain Dehydrogenases/Reductases (SDR) family comprises enzymes that catalyze the reduction of carbonyl groups on various substrates, including aldehydes and ketones. Members of the SDR family are involved in diverse biological processes, such as the biosynthesis of morphinan-type benzylisoquinoline and opiate alkaloids, resistance against pathogens, and the specific reduction of terpenoids. These enzymes exhibit stereospecificity in their catalytic activity and are known to undergo substrate inhibition, which may be due to conformational changes during catalysis or non-productive substrate binding modes. The family's broad substrate specificity includes compounds with more than five carbons and monoterpenes, highlighting their role in plant secondary metabolism and defense mechanisms.
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