PTHR43749

RNA-splicing ligase RtcB-like
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameRtcB-like
AI

Description

AI-generatedUnreviewed
This family of proteins includes GTP-dependent RNA ligases that play a crucial role in RNA splicing and repair mechanisms. They are capable of joining RNA molecules with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Additionally, these proteins exhibit versatility by acting as DNA ligases to repair 'dirty' DNA breaks, which are characterized by 3'-phosphate (or cyclic-phosphate) and 5'-hydroxy ends that are not amenable to repair by classical DNA ligases. Their ability to work on both RNA and DNA substrates underscores their importance in cellular maintenance and genome integrity.
Integrated to
External Links
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.