This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | EngA_Der_GTPase AI |
Description
AI-generatedUnreviewed
The EngA (Der) GTPase family consists of essential GTPases that play a crucial role in the late steps of ribosome biogenesis. Members of this family are characterized by the presence of two G (guanine nucleotide-binding) domains, which are essential for activity and function cooperatively. Additionally, these proteins typically contain a KH-like domain required for ribosome recognition. The GTPase activity of these proteins is vital for the stability and proper assembly of the 50S ribosomal subunit into functional 70S ribosomes. Mutations in these GTPases can be suppressed by overexpression of certain response mediators, indicating a possible interaction with 23S rRNA or r-protein complexes. The EngA (Der) GTPase family is part of the larger TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily.