PTHR43846

tRNA Uridine(34) Hydroxylase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameTrhO
AI

Description

AI-generatedUnreviewed
The TrhO family proteins are responsible for the post-transcriptional modification of tRNA by catalyzing the oxygen-dependent hydroxylation of uridine at position 34, resulting in the formation of 5-hydroxyuridine (ho5U). This modification is a key step in the biosynthesis of 5-carboxymethoxyuridine (cmo5U), which is essential for the proper decoding function of tRNAs during protein synthesis. Some members of the TrhO family may also participate in an alternate pathway that can bypass cmo5U biogenesis in certain tRNAs under aerobic conditions, highlighting a potential regulatory mechanism for tRNA function in response to oxygen availability.
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