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Member database | PANTHER |
PANTHER type | family |
Short name | DnaJ_subfamily_B/C AI |
Description
AI-generatedUnreviewed
This family of proteins functions as co-chaperones that work in conjunction with HSPA8/Hsc70 to promote protein folding, trafficking, and prevent aggregation of client proteins. They are involved in the endoplasmic reticulum-associated degradation (ERAD) pathway, influencing HSPA8/Hsc70's ATPase and polypeptide-binding activities. Some members can also operate independently of HSPA8/Hsc70, particularly in the maturation of potassium channels by stabilizing nascent subunits and aiding in their assembly into tetramers. Overexpression of certain members leads to the formation of nuclear membranous structures, the function of which is not fully understood. Additionally, some members are implicated in the penetration of polyomavirus into the endoplasmic reticulum membrane during infection.