PTHR43977

Structural Maintenance of Chromosomes (SMC)
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameSMC
AI

Description

AI-generatedUnreviewed
The SMC protein family is essential for chromosomal organization, segregation, and DNA repair. Members of the family play a crucial role in chromosome condensation and partitioning during cell division. They form complexes such as cohesin and condensin, which are necessary for maintaining sister chromatid cohesion and converting interphase chromatin into condensed mitotic chromosomes, respectively. These complexes may act as proteinaceous rings that trap sister chromatids or introduce supercoils into DNA. The SMC proteins are characterized by large globular ATPase domains, a central flexible hinge domain, and coiled-coil regions that facilitate the formation of V-shaped heterodimers and ring structures essential for their function in the cell cycle.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.