PTHR44129

WD repeat LIS1/nudF dynein regulation
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameWD_LIS1/nudF_dynein_reg
AI

Description

AI-generatedUnreviewed
The WD repeat LIS1/nudF family is involved in the regulation of the minus-end directed microtubule motor protein dynein. Family members play a crucial role in cellular processes such as mitotic spindle positioning, nuclear migration, and microtubule-dependent transport. They may enhance dynein-mediated microtubule sliding by targeting dynein to microtubule plus ends and are essential for various dynein-dependent processes including Golgi integrity, transport of microtubule fragments, and centrosome coupling. Some members also participate in the inactivation of platelet-activating factor (PAF) by serving as regulatory subunits of the cytosolic type I PAF acetylhydrolase. They are implicated in neuronal development, including the proliferation and migration of neuronal precursors, and may influence cell locomotion and actin polymerization in response to calcium influx.
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