This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | WD_LIS1/nudF_dynein_reg AI |
Description
AI-generatedUnreviewed
The WD repeat LIS1/nudF family is involved in the regulation of the minus-end directed microtubule motor protein dynein. Family members play a crucial role in cellular processes such as mitotic spindle positioning, nuclear migration, and microtubule-dependent transport. They may enhance dynein-mediated microtubule sliding by targeting dynein to microtubule plus ends and are essential for various dynein-dependent processes including Golgi integrity, transport of microtubule fragments, and centrosome coupling. Some members also participate in the inactivation of platelet-activating factor (PAF) by serving as regulatory subunits of the cytosolic type I PAF acetylhydrolase. They are implicated in neuronal development, including the proliferation and migration of neuronal precursors, and may influence cell locomotion and actin polymerization in response to calcium influx.