PTHR45008

Phosphotransferase system EIIA component
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short namePTS_EIIA_component
AI

Description

AI-generatedUnreviewed
The protein family consists of phosphotransferase enzyme IIA components that are integral to the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a key carbohydrate active transport system. Members of the family catalyze the phosphorylation of sugar substrates while facilitating their translocation across the cell membrane. Typically, the EIIA domain within these proteins is phosphorylated by phospho-HPr on a histidine residue, which then transfers the phosphoryl group to the EIIB domain. This process is crucial for the transport of glucose and potentially other sugars, playing a significant role in cellular metabolism and regulation. Some family members are also involved in the regulation of other sugar uptake systems and may influence the activity of adenylate cyclase when phosphorylated.
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