PTHR45636

PAIRED BOX PROTEIN PAX-6-RELATED-RELATED

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR043565

PAX family members are transcription factors characterised by a ~128-amino-acid DNA-binding paired domain that makes sequence specific contacts with DNA
[2]
. In mammals, there are nine Pax proteins (PAX1-9). They regulate the morphogenesis of a wide range of organs and are key factors for the development of mammalian sensory organs such as the eye (Pax6, Pax2), nose (Pax6) and ears (Pax2, Pax8)
[1, 3]
.

References
Imported from IPR043565

1.Pax genes in eye development and evolution. Kozmik Z. Curr. Opin. Genet. Dev. 15, 430-8, (2005). View articlePMID: 15950457

2.Crystallization and preliminary X-ray diffraction analysis of the Pax9 paired domain bound to a DC5 enhancer DNA element. Narasimhan K, Hilbig A, Udayasuryan B, Jayabal S, Kolatkar PR, Jauch R. Acta Crystallogr F Struct Biol Commun 70, 1357-61, (2014). View articlePMID: 25286939

3.Pax genes: regulators of lineage specification and progenitor cell maintenance. Blake JA, Ziman MR. Development 141, 737-51, (2014). View articlePMID: 24496612

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