PTHR45742

Complement C6/C7/C8/C9 membrane attack complex
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameComplement_C6-C9_MAC
AI

Description

AI-generatedUnreviewed
The complement C6/C7/C8/C9 family includes proteins that are constituents of the membrane attack complex (MAC), which is crucial for the innate and adaptive immune response. The MAC forms pores in the plasma membrane of target cells, leading to cell lysis. Members of this family share structural similarities and contribute to the formation and function of the MAC. C9 is the pore-forming subunit, while C8 beta and alpha chains, C7, and C6 are involved in the assembly and membrane insertion of the complex. C7 serves as a membrane anchor, and C8A inserts into the target membrane but does not form pores by itself.
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