PTHR45818

Rho GTPase guanine nucleotide exchange factor
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameRho_GEF
AI

Description

AI-generatedUnreviewed
This family of proteins functions as guanine nucleotide exchange factors (GEFs) for Rho family GTPases, including RhoA, RhoG, and Rac1. They are involved in various cellular processes such as angiogenesis, cell migration, assembly, differentiation, and proliferation. These proteins interact with phosphorylated tyrosine kinases and are important for integrin-mediated signaling pathways in certain cell types. They play a role in cytoskeleton organization and function in osteoclasts, wound healing, and macrophage phagocytosis. Some family members are implicated in the regulation of intracellular calcium concentrations and are essential for rhythmic behaviors in organisms.
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