This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | Rho_GEF AI |
Description
AI-generatedUnreviewed
This family of proteins functions as guanine nucleotide exchange factors (GEFs) for Rho family GTPases, including RhoA, RhoG, and Rac1. They are involved in various cellular processes such as angiogenesis, cell migration, assembly, differentiation, and proliferation. These proteins interact with phosphorylated tyrosine kinases and are important for integrin-mediated signaling pathways in certain cell types. They play a role in cytoskeleton organization and function in osteoclasts, wound healing, and macrophage phagocytosis. Some family members are implicated in the regulation of intracellular calcium concentrations and are essential for rhythmic behaviors in organisms.
External Links
Representative structure
2vrw: Critical structural role for the PH and C1 domains of the Vav1 exchange factor