PTHR45975

NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR038028

This entry includes the nucleosome-remodeling factor subunits BPTF (vertebrates) and NURF301 (Drosophila melanogaster), which are components of the NURF (nucleosome-remodeling factor) complex
[3, 1]
. The NURF complex catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin
[2]
. The HMGA/HMGI(Y)-like DNA-binding site of NURF301 facilitates nucleosome sliding
[3]
. BPTF binds histone H3K4me3 via its PHD zinc finger domain
[4]
, and interacts with the myc-associated zinc finger protein MAZ, altering its transcriptional activity,
[5]
and the Kelch-like Ech-associated protein KEAP1
[6]
.

References
Imported from IPR038028

1.Isolation of human NURF: a regulator of Engrailed gene expression. Barak O, Lazzaro MA, Lane WS, Speicher DW, Picketts DJ, Shiekhattar R. EMBO J. 22, 6089-100, (2003). View articlePMID: 14609955

2.Biological functions of the ISWI chromatin remodeling complex NURF. Badenhorst P, Voas M, Rebay I, Wu C. Genes Dev. 16, 3186-98, (2002). View articlePMID: 12502740

3.Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions. Xiao H, Sandaltzopoulos R, Wang HM, Hamiche A, Ranallo R, Lee KM, Fu D, Wu C. Mol. Cell 8, 531-43, (2001). View articlePMID: 11583616

4.A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, Kauer M, Tackett AJ, Chait BT, Badenhorst P, Wu C, Allis CD. Nature 442, 86-90, (2006). View articlePMID: 16728976

5.Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity. Jordan-Sciutto KL, Dragich JM, Caltagarone J, Hall DJ, Bowser R. Biochemistry 39, 3206-15, (2000). View articlePMID: 10727212

6.Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein. Strachan GD, Morgan KL, Otis LL, Caltagarone J, Gittis A, Bowser R, Jordan-Sciutto KL. Biochemistry 43, 12113-22, (2004). View articlePMID: 15379550

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