This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | SETDB_methyltransferase AI |
Description
AI-generatedUnreviewed
This family of proteins includes histone-lysine N-methyltransferases that are primarily involved in the methylation of 'Lys-9' of histone H3, which is a key epigenetic mark for transcriptional repression. They recruit heterochromatin protein 1 (HP1) to methylated histones, thereby playing a central role in the regulation of gene expression during various biological processes such as oogenesis, embryonic development, and mitosis. These proteins are also implicated in the silencing of euchromatic genes, tumor suppressor genes, and in maintaining a repressive state of genes in embryonic stem cells. The methylation activity of these proteins is crucial for chromosome condensation and segregation, and they are involved in protecting genomic stability by suppressing transcription-induced replication stress.
Integrated to
External Links
Representative structure
5tfp: Crystal Structure of the SETDB2 Amino Terminal Domain