PTHR46076

E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR043540

E3 ubiquitin-protein ligase RING1 (
2.3.2.27
) is one of the three E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, which is a specific tag for repression of epigenetic transcription and particularly for inactivation of chromosome X of female mammals
[7, 6]
. RING1 is a component of the Polycomb group (PcG) multiprotein PRC1-like complex, the repressive BCOR complex
[4]
, and the the E2F6.com-1 complex in G0 phase
[5]
. RING1 has a RING-type zinc finger.

E3 ubiquitin-protein ligase RING2 (
2.3.2.27
) mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub)
[2]
, which is a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals
[1]
. RING2 is a component of the PRC1 complex
[2]
, and other chromatin-associated Polycomb (PcG) complexes such as BCOR
[4]
. It is also a component of the MLL1/MLL complex
[3]
.

This entry includes E3 ubiquitin-protein ligase RING1/RING2.

References
Imported from IPR043540

1.Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. Li Z, Cao R, Wang M, Myers MP, Zhang Y, Xu RM. J. Biol. Chem. 281, 20643-9, (2006). View articlePMID: 16714294

2.Role of histone H2A ubiquitination in Polycomb silencing. Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y. Nature 431, 873-8, (2004). View articlePMID: 15386022

3.Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis CD, Chait BT, Hess JL, Roeder RG. Cell 121, 873-85, (2005). View articlePMID: 15960975

4.Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ. Mol. Cell. Biol. 26, 6880-9, (2006). View articlePMID: 16943429

5.A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y. Science 296, 1132-6, (2002). View articlePMID: 12004135

6.Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. de Napoles M, Mermoud JE, Wakao R, Tang YA, Endoh M, Appanah R, Nesterova TB, Silva J, Otte AP, Vidal M, Koseki H, Brockdorff N. Dev. Cell 7, 663-76, (2004). View articlePMID: 15525528

7.Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Cao R, Tsukada Y, Zhang Y. Mol. Cell 20, 845-54, (2005). View articlePMID: 16359901

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