PTHR46403

TP53-REGULATED INHIBITOR OF APOPTOSIS 1

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR007918

This is a family of small highly conserved proteins. In Saccharomyces cerevisiae (Baker's yeast) the gene YKL053C-A (MDM35)
O60200
is one of the genes essential for maintenance of normal mitochondrial distribution and morphology (MDM)
[1]
; wherease in Homo sapiens (Human), p53CSV,
O43715
is a direct transcriptional target for p53 and appears to be a cell-survival mediator in response to genotoxic stress including low-levels of DNA damage. It is suggested that p53CSV modulates the apoptotic pathway through interaction with HSP70 and Apaf-1 thereby inhibiting activation of procaspase-3 and procaspase-9
[2]
.

References
Imported from IPR007918

1.Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Dimmer KS, Fritz S, Fuchs F, Messerschmitt M, Weinbach N, Neupert W, Westermann B. Mol. Biol. Cell 13, 847-53, (2002). View articlePMID: 11907266

2.p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway. Park WR, Nakamura Y. Cancer Res. 65, 1197-206, (2005). View articlePMID: 15735003

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