PTHR46530

PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR031273

PARP4, also known as vPARP, is the largest member of the poly-ADP-ribose polymerase (PARP) family. PARP4 exhibits PARP activity and can PARylate major vault protein (MVP) and, to a lesser extent, itself. Vaults are the largest ribonucleoprotein particles found in eukaryotic cells
[2]
.

Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins
[1]
. PARP family members are PAR polymerases that initiate the reaction by converting the substrate nicotinamide adenine dinucleotide (NAD+) to ADP-ribose, and then catalyse ADP-ribose polymerisation on nuclear acceptor proteins
[2]
.

References
Imported from IPR031273

1.Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. D'Amours D, Desnoyers S, D'Silva I, Poirier GG. Biochem. J. 342 ( Pt 2), 249-68, (1999). View articlePMID: 10455009

2.The poly(ADP-ribose) polymerases (PARPs): new roles in intracellular transport. Abd Elmageed ZY, Naura AS, Errami Y, Zerfaoui M. Cell. Signal. 24, 1-8, (2012). View articlePMID: 21840394

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