PTHR46676

PROTEIN AMBP

PANTHER entry
Member databasePANTHER
PANTHER typefamily

Description
Imported from IPR029856

Protein AMBP is a precursor that gives rise to two different secreted proteins upon endopeptidase cleavage in hepatocytes
[1]
. One of the two proteins after cleavage, alpha1-microglobulin is a glycoprotein that belongs to the lipocalin family. It has immunoregulatory properties and is involved in heme-catabolism
[4, 3]
. The second protein, bikunin, is a Kunitz-type proteinase inhibitor of the inter-alpha-inhibitor family
[2]
.

References
Imported from IPR029856

1.Expression of the AMBP gene transcript and its two protein products, alpha(1)-microglobulin and bikunin, in mouse embryogenesis. Sanchez D, Martinez S, Lindqvist A, Akerstrom B, Falkenberg C. Mech. Dev. 117, 293-8, (2002). View articlePMID: 12204273

2.The inter-alpha-inhibitor family: from structure to regulation. Salier JP, Rouet P, Raguenez G, Daveau M. Biochem. J. 315 ( Pt 1), 1-9, (1996). PMID: 8670091

3.Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties. Allhorn M, Berggard T, Nordberg J, Olsson ML, Akerstrom B. Blood 99, 1894-901, (2002). View articlePMID: 11877257

4.Immunosuppressive properties of alpha 1-microglobulin. Logdberg L, Akerstrom B. Scand. J. Immunol. 13, 383-90, (1981). View articlePMID: 6171029

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