This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member database | PANTHER |
PANTHER type | family |
Short name | E3_ligase_sorting_rcpt AI |
Description
AI-generatedUnreviewed
This family of proteins is involved in various cellular processes including protein ubiquitination, signaling pathway regulation, protein trafficking, and cellular growth control. Members of this family function as E3 ubiquitin-protein ligases, catalyzing the attachment of ubiquitin to substrate proteins, thereby targeting them for degradation or altering their cellular location and function. They play roles in the regulation of the TORC1 signaling pathway through polyubiquitination of specific proteins, influencing nutrient response and growth regulation. Some members are also implicated in the sorting and trafficking of proteins to vacuoles, acting as sorting receptors. Additionally, they are involved in synaptic transmission regulation and endosomal trafficking by mediating ubiquitination of receptors and vesicular proteins. The family includes proteins that regulate lysosome positioning and are involved in the G1/S transition of the cell cycle.