PTHR47386

TNF and chemokine receptor-like
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameTNF_chemokine_rcpt-like
AI

Description

AI-generatedUnreviewed
This family of proteins includes receptors that interact with tumor necrosis factor (TNF) and chemokines. They are involved in modulating the immune response by binding to these signaling molecules in the extracellular space, which inhibits the host's immune defense mechanisms. Some members mimic host TNF receptors and can bind TNF with high affinity, potentially preventing TNF from reaching its cellular targets and dampening its antiviral effects. The family also includes viral proteins that can bind host chemokines, thereby interfering with chemokine-mediated immune responses.
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