PTHR47674

SAGA-associated factor 11
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameSGF11
AI

Description

AI-generatedUnreviewed
This family of proteins includes components of the SAGA deubiquitination module, which has a role in chromatin modification through the deubiquitination of monoubiquitinated histone H2B. Members of this family are also involved in transcriptional regulation by influencing RNA polymerase II activity via various mechanisms, including interaction with transcription activators and the basal transcription machinery, as well as through histone acetylation. The proteins contain a C-terminal SGF11-type zinc-finger domain that forms part of the catalytic lobe of the SAGA complex, and a long N-terminal helix that contributes to the assembly lobe of the complex.
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