PTHR48109

Dihydroorotate dehydrogenase
AI

PANTHER entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Member databasePANTHER
PANTHER typefamily
Short nameDHO_dehydrogenase
AI

Description

AI-generatedUnreviewed
The dihydroorotate dehydrogenase family is involved in the de novo pyrimidine biosynthesis pathway. Members of this family catalyze the stereospecific oxidation of (S)-dihydroorotate to orotate, a critical step in the production of UMP, which is a precursor for all other pyrimidine nucleotides. The enzymes within this family are classified into two subfamilies based on their electron acceptors: Type 1 subfamily members use NAD(+) as the electron acceptor, while Type 2 subfamily members utilize quinone. Some members can also use fumarate as an alternative electron acceptor. The activity of these enzymes is essential for the synthesis of pyrimidine nucleotides required for DNA and RNA production in organisms.
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