PF00018

SH3 domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameSH3_1
ClanSH3
AuthorCerutti L; Sonnhammer ELL;0000-0002-9015-5588 Eddy SR;0000-0001-6676-4706 Finn RD;0000-0001-8626-2148
Sequence Ontology0000417

Description

SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.

References

1. Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p. Kami K, Takeya R, Sumimoto H, Kohda D. EMBO J. 21, 4268-76, (2002). View articlePMID: 12169629

Wikipedia

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.