Member database | Pfam |
Pfam type | domain |
Short name | SH3_1 |
Clan | SH3 |
Author | Cerutti L; Sonnhammer ELL;0000-0002-9015-5588 Eddy SR;0000-0001-6676-4706 Finn RD;0000-0001-8626-2148 |
Sequence Ontology | 0000417 |
Description
SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.
References
1. Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p. Kami K, Takeya R, Sumimoto H, Kohda D. EMBO J. 21, 4268-76, (2002). View articlePMID: 12169629
Integrated to
Representative structure
1zuu: Crystal structure of the yeast Bzz1 first SH3 domain at 0.97-A resolution