Member database | Pfam |
Pfam type | domain |
Short name | Connexin |
Clan | Transporter |
Author | Sonnhammer ELL;0000-0002-9015-5588 |
Sequence Ontology | 0000417 |
Description
Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.
References
1. Sequence and phylogenetic analyses of 4 TMS junctional proteins of animals: connexins, innexins, claudins and occludins. Hua VB, Chang AB, Tchieu JH, Kumar NM, Nielsen PA, Saier MH Jr. J Membr Biol 194, 59-76, (2003). View articlePMID: 14502443
Integrated to
Representative structure
7qeq: human Connexin 26 dodecamer at 90mmHg PCO2, pH7.4