PF00226

DnaJ domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameDnaJ
ClanChaperone-J
Author Birney E;0000-0001-8314-8497 Finn RD;0000-0001-8626-2148
Sequence Ontology0000417

Description

DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature
[1]
.

References

1.Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Stubdal H, Zalvide J, Campbell KS, Schweitzer C, Roberts TM, DeCaprio JA. Mol. Cell. Biol. 17, 4979-90, (1997). View articlePMID: 9271376

Further reading

2. The J-domain family and the recruitment of chaperone power. Kelley WL. Trends Biochem. Sci. 23, 222-7, (1998). View articlePMID: 9644977

3. DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70. Cyr DM, Langer T, Douglas MG. Trends Biochem. Sci. 19, 176-81, (1994). View articlePMID: 8016869

4. NMR structure of the J-domain and the Gly/Phe-rich region of the Escherichia coli DnaJ chaperone. Pellecchia M, Szyperski T, Wall D, Georgopoulos C, Wuthrich K. J. Mol. Biol. 260, 236-50, (1996). View articlePMID: 8764403

Wikipedia

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