Member database | Pfam |
Pfam type | domain |
Short name | Thymidylat_synt |
Author | Finn RD;0000-0001-8626-2148 |
Sequence Ontology | 0000417 |
Description
This is a family of proteins that are flavin-dependent thymidylate synthases.
References
1. An alternative flavin-dependent mechanism for thymidylate synthesis. Myllykallio H, Lipowski G, Leduc D, Filee J, Forterre P, Liebl U. Science 297, 105-7, (2002). View articlePMID: 12029065
2. Two distinct pathways for thymidylate (dTMP) synthesis in (hyper)thermophilic Bacteria and Archaea. Leduc D, Graziani S, Meslet-Cladiere L, Sodolescu A, Liebl U, Myllykallio H. Biochem. Soc. Trans. 32, 231-5, (2004). View articlePMID: 15046578
3. Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria. Leduc D, Escartin F, Nijhout HF, Reed MC, Liebl U, Skouloubris S, Myllykallio H. J Bacteriol 189, 8537-45, (2007). PMID: 17890305
Integrated to
Representative structure
6nnr: high-resolution structure of wild-type E. coli thymidylate synthase