PF00379

Insect cuticle protein

Pfam entry
Member databasePfam
Pfam typedomain
Short nameChitin_bind_4
Author Finn RD;0000-0001-8626-2148 Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

Many insect cuticular proteins include a 35-36 amino acid motif known as the R&R consensus. The extensive conservation of this region led to the suggestion that it functions to bind chitin. Provocatively, it has no sequence similarity to the well-known cysteine-containing chitin-binding domain found in chitinases and some peritrophic membrane proteins. Chitin binding has been shown experimentally for this region
[1]
. Thus arthropods have two distinct classes of chitin binding proteins, those with the chitin-binding domain found in lectins, chitinases and peritrophic membranes (cysCBD) and those with the cuticular protein chitin-binding domain (non-cysCBD)
[1]
.

References

1.A conserved domain in arthropod cuticular proteins binds chitin. Rebers JE, Willis JH. Insect Biochem. Mol. Biol. 31, 1083-93, (2001). View articlePMID: 11520687

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