PF00415

Regulator of chromosome condensation (RCC1) repeat

Pfam entry
Member databasePfam
Pfam typerepeat
Short nameRCC1
ClanBeta_propeller
Author Finn RD;0000-0001-8626-2148
Sequence Ontology0001068

Description
Imported from IPR000408

The regulator of chromosome condensation (RCC1)
[1]
is a eukaryotic protein which binds to chromatin and interacts with ran, a nuclear GTP-binding protein
IPR002041
, to promote the loss of bound GDP and the uptake of fresh GTP, thus acting as a guanine-nucleotide dissociation stimulator (GDS). The interaction of RCC1 with ran probably plays an important role in the regulation of gene expression.

RCC1, known as PRP20 or SRM1 in yeast, pim1 in fission yeast and BJ1 in Drosophila, is a protein that contains seven tandem repeats of a domain of about 50 to 60 amino acids. As shown in the following schematic representation, the repeats make up the major part of the length of the protein. Outside the repeat region, there is just a small N-terminal domain of about 40 to 50 residues and, in the Drosophila protein only, a C-terminal domain of about 130 residues.

+----+-------+-------+-------+-------+-------+-------+-------+-------------+
|N-t.|Rpt. 1 |Rpt. 2 |Rpt. 3 |Rpt. 4 |Rpt. 5 |Rpt. 6 |Rpt. 7 | C-terminal  |
+----+-------+-------+-------+-------+-------+-------+-------+-------------+

The RCC1-type of repeat is also found in the X-linked retinitis pigmentosa GTPase regulator
[2]
. The RCC repeats form a β-propeller structure.

References
Imported from IPR000408

1.RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles. Dasso M. Trends Biochem. Sci. 18, 96-101, (1993). View articlePMID: 8480369

2.Positional cloning of the gene for X-linked retinitis pigmentosa 3: homology with the guanine-nucleotide-exchange factor RCC1. Roepman R, van Duijnhoven G, Rosenberg T, Pinckers AJ, Bleeker-Wagemakers LM, Bergen AA, Post J, Beck A, Reinhardt R, Ropers HH, Cremers FP, Berger W. Hum. Mol. Genet. 5, 1035-41, (1996). View articlePMID: 8817343

Integrated to
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.