PF00424

REV protein (anti-repression trans-activator protein)

Pfam entry
Member databasePfam
Pfam typefamily
Short nameREV
Author Finn RD;0000-0001-8626-2148
Sequence Ontology0100021

Description
Imported from IPR000625

REV is a viral anti-repression trans-activator protein, which appears to act post-transcriptionally
[1]
to relieve negative repression of GAG and ENV production. It is a phosphoprotein
[2, 3]
whose state of phosphorylation is mediated by a specific serine kinase activity present in the nucleus
[2]
. REV accumulates in the nucleoli
[4]
.

References
Imported from IPR000625

1.Functional significance of phosphorylation to the human immunodeficiency virus Rev protein. Cochrane AW, Golub E, Volsky D, Ruben S, Rosen CA. J. Virol. 63, 4438-40, (1989). View articlePMID: 2550674

2.The human immunodeficiency virus rev protein is a nuclear phosphoprotein. Cochrane A, Kramer R, Ruben S, Levine J, Rosen CA. Virology 171, 264-6, (1989). View articlePMID: 2741343

3.Phosphorylation of the rev gene product of human immunodeficiency virus type 1. Hauber J, Bouvier M, Malim MH, Cullen BR. J. Virol. 62, 4801-4, (1988). View articlePMID: 2846891

4.Structural and functional characterization of the human immunodeficiency virus rev protein. Perkins A, Cochrane AW, Ruben SM, Rosen CA. J. Acquir. Immune Defic. Syndr. 2, 256-63, (1989). PMID: 2656990

Wikipedia

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.