Member database | Pfam |
Pfam type | family |
Short name | REV |
Author | Finn RD;0000-0001-8626-2148 |
Sequence Ontology | 0100021 |
Description Imported from IPR000625
REV is a viral anti-repression trans-activator protein, which appears to act post-transcriptionally
[1] to relieve negative repression of GAG and ENV production. It is a phosphoprotein
[2, 3] whose state of phosphorylation is mediated by a specific serine kinase activity present in the nucleus
[2]. REV accumulates in the nucleoli
[4].
References Imported from IPR000625
1.Functional significance of phosphorylation to the human immunodeficiency virus Rev protein. Cochrane AW, Golub E, Volsky D, Ruben S, Rosen CA. J. Virol. 63, 4438-40, (1989). View articlePMID: 2550674
2.The human immunodeficiency virus rev protein is a nuclear phosphoprotein. Cochrane A, Kramer R, Ruben S, Levine J, Rosen CA. Virology 171, 264-6, (1989). View articlePMID: 2741343
3.Phosphorylation of the rev gene product of human immunodeficiency virus type 1. Hauber J, Bouvier M, Malim MH, Cullen BR. J. Virol. 62, 4801-4, (1988). View articlePMID: 2846891