PF00501

AMP-binding enzyme

Pfam entry
Member databasePfam
Pfam typefamily
Short nameAMP-binding
ClanANL
Author Finn RD;0000-0001-8626-2148 Eberhardt R;0000-0001-6152-1369
Sequence Ontology0100021

Description
Imported from IPR000873

This domain is found in a number of prokaryotic and eukaryotic enzymes, which appear to act via an ATP-dependent covalent binding of AMP to their substrate, share a region of sequence similarity
[1, 2, 3]
. This region is a Ser/Thr/Gly-rich domain that is further characterised by a conserved Pro-Lys-Gly triplet. This group of enzymes includes luciferase, long chain fatty acid Co-A ligase, long-chain fatty acid transport proteins that also function as acyl-CoA ligases, acetyl-CoA synthetase and various other closely-related synthetases
[5, 6, 4]
.

References
Imported from IPR000873

1.The multifunctional peptide synthetase performing the first step of penicillin biosynthesis in Penicillium chrysogenum is a 421,073 dalton protein similar to Bacillus brevis peptide antibiotic synthetases. Smith DJ, Earl AJ, Turner G. EMBO J. 9, 2743-50, (1990). View articlePMID: 2118102

2.Protein sequence homology between plant 4-coumarate:CoA ligase and firefly luciferase. Schroder J. Nucleic Acids Res. 17, 460, (1989). View articlePMID: 2911486

3.Cloning and sequencing of a bile acid-inducible operon from Eubacterium sp. strain VPI 12708. Mallonee DH, White WB, Hylemon PB. J. Bacteriol. 172, 7011-9, (1990). View articlePMID: 2254270

4.Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast. DiRusso CC, Li H, Darwis D, Watkins PA, Berger J, Black PN. J Biol Chem 280, 16829-37, (2005). PMID: 15699031

5.Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes. Conti E, Franks NP, Brick P. Structure 4, 287-98, (1996). View articlePMID: 8805533

6.Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis. Jackson DR, Tu SS, Nguyen M, Barajas JF, Schaub AJ, Krug D, Pistorius D, Luo R, Muller R, Tsai SC. ACS Chem. Biol. 11, 95-103, (2016). View articlePMID: 26473393

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