Member database | Pfam |
Pfam type | domain |
Short name | Vpu |
Author | Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0000417 |
Description
The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing the release of viral particles from infected cells. The VPU protein binds specifically to CD4.
References
1. The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation. Bour S, Schubert U, Strebel K. J. Virol. 69, 1510-20, (1995). View articlePMID: 7853484
2. Enhancement of retroviral production from packaging cell lines expressing the human immunodeficiency type 1 VPU gene. Kobinger GP, Mouland AJ, Lalonde JP, Forget J, Cohen EA. Gene Ther. 4, 868-74, (1997). View articlePMID: 9338017
3. Secondary structure and tertiary fold of the human immunodeficiency virus protein U (Vpu) cytoplasmic domain in solution. Willbold D, Hoffmann S, Rosch P. Eur. J. Biochem. 245, 581-8, (1997). View articlePMID: 9182993