Member database | Pfam |
Pfam type | domain |
Short name | Vpu |
Author | Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0000417 |
Description
The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing the release of viral particles from infected cells. The VPU protein binds specifically to CD4.
References
1. Enhancement of retroviral production from packaging cell lines expressing the human immunodeficiency type 1 VPU gene. Kobinger GP, Mouland AJ, Lalonde JP, Forget J, Cohen EA. Gene Ther. 4, 868-74, (1997). View articlePMID: 9338017
2. Secondary structure and tertiary fold of the human immunodeficiency virus protein U (Vpu) cytoplasmic domain in solution. Willbold D, Hoffmann S, Rosch P. Eur. J. Biochem. 245, 581-8, (1997). View articlePMID: 9182993
3. The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation. Bour S, Schubert U, Strebel K. J. Virol. 69, 1510-20, (1995). View articlePMID: 7853484