PF00562

RNA polymerase Rpb2, domain 6

Pfam entry
Member databasePfam
Pfam typedomain
Short nameRNA_pol_Rpb2_6
ClanLEF-8-like
Author Finn RD;0000-0001-8626-2148
Sequence Ontology0000417

Description

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain
[1]
. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion
[1]
. This domain is also involved in binding to Rpb1 and Rpb3
[1]
. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).

References

1.Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Cramer P, Bushnell DA, Kornberg RD. Science 292, 1863-76, (2001). View articlePMID: 11313498

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