PF00568

WH1 domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameWH1
ClanPH
AuthorSMART;
Sequence Ontology0000417

Description

WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue
[2]
. A subset of WH1 domains has been termed a "EVH1" domain
[1]
and appear to bind a polyproline motif.

References

1.A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family. Niebuhr K, Ebel F, Frank R, Reinhard M, Domann E, Carl UD, Walter U, Gertler FB, Wehland J, Chakraborty T. EMBO J. 16, 5433-44, (1997). View articlePMID: 9312002

2.Identification of homer as a homologue of the Wiskott-Aldrich syndrome protein suggests a receptor-binding function for WH1 domains. Ponting CP, Phillips C. J. Mol. Med. 75, 769-71, (1997). View articlePMID: 9428607

Further reading

3. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Symons M, Derry JM, Karlak B, Jiang S, Lemahieu V, Mccormick F, Francke U, Abo A. Cell 84, 723-34, (1996). View articlePMID: 8625410

Wikipedia

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