PF00570

HRDC domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameHRDC
ClanHRDC-like
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains
[1]
.

References

1.Three tandem HRDC domains have synergistic effect on the RecQ functions in Deinococcus radiodurans. Huang L, Hua X, Lu H, Gao G, Tian B, Shen B, Hua Y. DNA Repair (Amst.) 6, 167-76, (2007). View articlePMID: 17085080

Further reading

2. The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins. Liu Z, Macias MJ, Bottomley MJ, Stier G, Linge JP, Nilges M, Bork P, Sattler M. Structure 7, 1557-66, (1999). View articlePMID: 10647186

3. A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases. Morozov V, Mushegian AR, Koonin EV, Bork P. Trends Biochem. Sci. 22, 417-8, (1997). View articlePMID: 9397680

4. The HRDC domain of BLM is required for the dissolution of double Holliday junctions. Wu L, Chan KL, Ralf C, Bernstein DA, Garcia PL, Bohr VA, Vindigni A, Janscak P, Keck JL, Hickson ID. EMBO J. 24, 2679-87, (2005). View articlePMID: 15990871

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