Member database | Pfam |
Pfam type | family |
Short name | Phage_integrase |
Clan | DNA-mend |
Author | Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0100021 |
Description
Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase (Swiss:P06956) are Arg-173, His-289, Arg-292 and Tyr-324.
References
1. Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse. Guo F, Gopaul DN, van Duyne GD. Nature 389, 40-6, (1997). View articlePMID: 9288963
2. Flexibility in DNA recombination: structure of the lambda integrase catalytic core. Kwon HJ, Tirumalai R, Landy A, Ellenberger T. Science 276, 126-31, (1997). View articlePMID: 9082984
Integrated to
Representative structure
1ae9: STRUCTURE OF THE LAMBDA INTEGRASE CATALYTIC CORE