PF00589

Phage integrase family

Pfam entry
Member databasePfam
Pfam typefamily
Short namePhage_integrase
ClanDNA-mend
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0100021

Description

Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase (Swiss:P06956) are Arg-173, His-289, Arg-292 and Tyr-324.

References

1. Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse. Guo F, Gopaul DN, van Duyne GD. Nature 389, 40-6, (1997). View articlePMID: 9288963

2. Flexibility in DNA recombination: structure of the lambda integrase catalytic core. Kwon HJ, Tirumalai R, Landy A, Ellenberger T. Science 276, 126-31, (1997). View articlePMID: 9082984

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