Member database | Pfam |
Pfam type | repeat |
Short name | PI3Ka |
Clan | TPR |
Author | Ponting CP;0000-0003-0202-7816 Schultz J; Bork P;0000-0002-2627-833X |
Sequence Ontology | 0001068 |
Description
PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested
[1] to be involved in substrate presentation.
References
1.Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability. Flanagan CA, Schnieders EA, Emerick AW, Kunisawa R, Admon A, Thorner J. Science 262, 1444-8, (1993). View articlePMID: 8248783
Further reading
2. Using structure to define the function of phosphoinositide 3-kinase family members. Domin J, Waterfield MD. FEBS Lett. 410, 91-5, (1997). View articlePMID: 9247130