PF00613

Phosphoinositide 3-kinase family, accessory domain (PIK domain)

Pfam entry
Member databasePfam
Pfam typerepeat
Short namePI3Ka
ClanTPR
Author Ponting CP;0000-0003-0202-7816 Schultz J; Bork P;0000-0002-2627-833X
Sequence Ontology0001068

Description

PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested
[1]
to be involved in substrate presentation.

References

1.Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability. Flanagan CA, Schnieders EA, Emerick AW, Kunisawa R, Admon A, Thorner J. Science 262, 1444-8, (1993). View articlePMID: 8248783

Further reading

2. Using structure to define the function of phosphoinositide 3-kinase family members. Domin J, Waterfield MD. FEBS Lett. 410, 91-5, (1997). View articlePMID: 9247130

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