PF00618

RasGEF N-terminal motif

Pfam entry
Member databasePfam
Pfam typedomain
Short nameRasGEF_N
ClanRAS_GEF_N
Author Ponting CP;0000-0003-0202-7816 Schultz J; Bork P;0000-0002-2627-833X
Sequence Ontology0000417

Description

A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.

References

1. The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Skolnik EY, Batzer A, Li N, Lee CH, Lowenstein E, Mohammadi M, Margolis B, Schlessinger J. Science 260, 1953-5, (1993). View articlePMID: 8316835

2. Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. Quilliam LA, Khosravi-Far R, Huff SY, Der CJ. Bioessays 17, 395-404, (1995). View articlePMID: 7786285

3. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J. Nature 363, 85-8, (1993). View articlePMID: 8479541

4. Proteins regulating Ras and its relatives. Boguski MS, McCormick F. Nature 366, 643-54, (1993). View articlePMID: 8259209

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