PF00631

GGL domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameG-gamma
Author Bateman A;0000-0002-6982-4660 Anantharaman V;0000-0001-8395-0009
Sequence Ontology0000417

Description

G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins
[2]
. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA
[1]
. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta
[1]
. All organisms that posses a G-beta possess a G-gamma
[1]
.

References

1.Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system. Anantharaman V, Abhiman S, de Souza RF, Aravind L. Gene 475, 63-78, (2011). View articlePMID: 21182906

2.A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP. Proc. Natl. Acad. Sci. U.S.A. 95, 13307-12, (1998). View articlePMID: 9789084

Wikipedia

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