Member database | Pfam |
Pfam type | domain |
Short name | G-gamma |
Author | Bateman A;0000-0002-6982-4660 Anantharaman V;0000-0001-8395-0009 |
Sequence Ontology | 0000417 |
Description
G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins
[2]. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA
[1]. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta
[1]. All organisms that posses a G-beta possess a G-gamma
[1].
References
1.Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system. Anantharaman V, Abhiman S, de Souza RF, Aravind L. Gene 475, 63-78, (2011). View articlePMID: 21182906
2.A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP. Proc. Natl. Acad. Sci. U.S.A. 95, 13307-12, (1998). View articlePMID: 9789084
Integrated to
Representative structure
8f0k: Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385