PF00670

S-adenosyl-L-homocysteine hydrolase, NAD binding domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameAdoHcyase_NAD
ClanNADP_Rossmann
Author Bateman A;0000-0002-6982-4660 Griffiths-Jones SR;0000-0001-6043-807X Finn RD;0000-0001-8626-2148
Sequence Ontology0000417

Description
Imported from IPR015878

S-adenosyl-L-homocysteine hydrolase (
3.3.1.1
) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. AdoHcyase is an ubiquitous enzyme which binds and requires NAD+as a cofactor. AdoHcyase is a highly conserved protein
[1]
of about 430 to 470 amino acids.

References
Imported from IPR015878

1.Mutational and nucleotide sequence analysis of S-adenosyl-L-homocysteine hydrolase from Rhodobacter capsulatus. Sganga MW, Aksamit RR, Cantoni GL, Bauer CE. Proc. Natl. Acad. Sci. U.S.A. 89, 6328-32, (1992). View articlePMID: 1631127

Wikipedia

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