Member database | Pfam |
Pfam type | domain |
Short name | AdoHcyase_NAD |
Clan | NADP_Rossmann |
Author | Bateman A;0000-0002-6982-4660 Griffiths-Jones SR;0000-0001-6043-807X Finn RD;0000-0001-8626-2148 |
Sequence Ontology | 0000417 |
Description Imported from IPR015878
S-adenosyl-L-homocysteine hydrolase (
3.3.1.1) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. AdoHcyase is an ubiquitous enzyme which binds and requires NAD+as a cofactor.
AdoHcyase is a highly conserved protein
[1] of about 430 to 470 amino acids.
References Imported from IPR015878
1.Mutational and nucleotide sequence analysis of S-adenosyl-L-homocysteine hydrolase from Rhodobacter capsulatus. Sganga MW, Aksamit RR, Cantoni GL, Bauer CE. Proc. Natl. Acad. Sci. U.S.A. 89, 6328-32, (1992). View articlePMID: 1631127