PF00714

Interferon gamma

Pfam entry
Member databasePfam
Pfam typedomain
Short nameIFN-gamma
Clan4H_Cytokine
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description
Imported from IPR002069

Interferon gamma (IFN-gamma) is produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma shows antiviral activity and has important immunoregulatory functions. It is a potent activator of microphages and had antiproliferative effects on transformed cells. It can potentiate the antiviral and antitumor effects of the type I interferons.

The crystal structures of a number IFN-gamma proteins have been solved, including bovine interferon-gamma at 2.0-A
[1]
and human IFN-gamma at 2.9-A
[2]
.

References
Imported from IPR002069

1.The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species. Randal M, Kossiakoff AA. Acta Crystallogr. D Biol. Crystallogr. 56, 14-24, (2000). View articlePMID: 10666622

2.Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma. Landar A, Curry B, Parker MH, DiGiacomo R, Indelicato SR, Nagabhushan TL, Rizzi G, Walter MR. J. Mol. Biol. 299, 169-79, (2000). View articlePMID: 10860730

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