Member database | Pfam |
Pfam type | domain |
Short name | IFN-gamma |
Clan | 4H_Cytokine |
Author | Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0000417 |
Description Imported from IPR002069
Interferon gamma (IFN-gamma) is produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma shows antiviral activity and has important immunoregulatory functions. It is a potent activator of microphages and had antiproliferative effects on transformed cells. It can potentiate the antiviral and antitumor effects of the type I interferons.
References Imported from IPR002069
1.The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species. Randal M, Kossiakoff AA. Acta Crystallogr. D Biol. Crystallogr. 56, 14-24, (2000). View articlePMID: 10666622
2.Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma. Landar A, Curry B, Parker MH, DiGiacomo R, Indelicato SR, Nagabhushan TL, Rizzi G, Walter MR. J. Mol. Biol. 299, 169-79, (2000). View articlePMID: 10860730
Integrated to
Representative structure
1d9c: BOVINE INTERFERON-GAMMA AT 2.0 ANGSTROMS