PF00856

SET domain

Pfam entry
Member databasePfam
Pfam typefamily
Short nameSET
ClanSAF
Author Bateman A;0000-0002-6982-4660 Huang S;0000-0003-2674-2830
Sequence Ontology0100021

Description

SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases)
[2]
. A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction
[1]
. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure
[3]
.

References

1.The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression. Huang S, Shao G, Liu L. J. Biol. Chem. 273, 15933-9, (1998). View articlePMID: 9632640

2.Association of SET domain and myotubularin-related proteins modulates growth control. Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML. Nat. Genet. 18, 331-7, (1998). View articlePMID: 9537414

3.Structure of SET domain proteins: a new twist on histone methylation. Marmorstein R. Trends Biochem. Sci. 28, 59-62, (2003). View articlePMID: 12575990

Further reading

4. The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD finger. Tripoulas N, LaJeunesse D, Gildea J, Shearn A. Genetics 143, 913-28, (1996). View articlePMID: 8725238

5. Structure of the SET domain histone lysine methyltransferase Clr4. Min J, Zhang X, Cheng X, Grewal SI, Xu RM. Nat. Struct. Biol. 9, 828-32, (2002). PMID: 12389037

Wikipedia

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