PF00941

FAD binding domain in molybdopterin dehydrogenase

Pfam entry
Member databasePfam
Pfam typefamily
Short nameFAD_binding_5
ClanFAD_PCMH
Author Finn RD;0000-0001-8626-2148 Bateman A;0000-0002-6982-4660 Griffiths-Jones SR;0000-0001-6043-807X
Sequence Ontology0100021

Description
Imported from IPR002346

Oxidoreductases, that also bind molybdopterin, have essentially no similarity outside this common domain. They include aldehyde oxidase (
1.2.3.1
), that converts an aldehyde and water to an acid and hydrogen peroxide, and xanthine dehydrogenase (
1.1.1.204
), that converts xanthine to urate. These enzymes require molybdopterin and FAD as cofactors and have and two 2FE-2S clusters. Another enzyme that contains this domain is the Pseudomonas thermocarboxydovorans carbon monoxide oxygenase and nicotine dehydrogenase involved in the degradation of nicotine.
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